A friend of mine is running DOS 6.22 in a virtual machine under XP. Can't remember if it's DOSBox or VirtualBOX, but it's one of the two. Install the VM and then just install DOS 6.22 as if you were installing it on a "legacy" machine. Both of the VM programs are free downloads.
In this instance, I think you'd want DOSBox. IIRC, it's pretty much fully-packaged with DOS 6.22 (or equivalent), whereas with VirtualBox you'd need to install DOS 6.22 after the fact (not like that's any kind of a challenge, of course).
Some programs run well under Legacy Compatibility under windows. In both XP and Vista, if you right-click on the executable (not a desktop shortcut, but the actual executable), and pull up the properties, there's a "Compatibility" (or some such) tab that allows you to declare NT, 95/98, and so on.
Since Win95 and Win98 were
not actual operating systems (merely presentation managers with crude task switching that ran on top of DOS), the legacy support environment may give you all you need.
I have a hard time believing that there's no other packages out there that can do what you need, but if you never look you'll never find them. It's not like all need for antenna design stopped in 1995.