Friend with a milling machine a best bet too...
But a whole bunch depends on if you are working with aluminum (easy) or steel (harder).
For steel the dremel cutoff wheels might be a good bet - the heavy duty ones, corners drilled first... although depending on the gauge the nibbler is ok too.
I used to have one of those nibbler tools - someone "borrowed" it back in the 70s... have not replaced it to date. Maybe I should. Not sure since I now have the milling machine, the router, the roto-zip, the dremel and some other devices...
_-_-bear